RESUMO
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in the world and renders those affected susceptible to potentially severe oxidative hemolysis. Although the resulting hemolysis is most often associated with drug exposure, it has also been reported after consumption of certain foods. With the exception of review articles that reiterated the historical knowledge that fava beans can provoke severe oxidative hemolysis in individuals with G6PD deficiency, very few articles have examined the safety of other food ingredients and food additives for people with G6PD deficiency. Some articles that associated specific foods with hemolysis appeared to be speculative and based on limited information. The objective of this review was to examine the association between foods, including food additives, and the triggering factors of acute hemolysis. The literature was searched for studies and case reports on food consumption and G6PD deficiency. In this review, fava beans were found to be the only food for which there is conclusive clinical evidence linking the risk of hemolytic anemia to individuals with G6PD deficiency. Food additives, at their permitted level of use in North America, can be consumed safely by most patients with G6PD deficiency.
Assuntos
Deficiência de Glucosefosfato Desidrogenase/dietoterapia , Animais , Alimentos/efeitos adversos , Hemólise , Humanos , Vicia faba/efeitos adversosAssuntos
Anemia Hemolítica/prevenção & controle , Corantes de Alimentos/efeitos adversos , Alimentos/efeitos adversos , Deficiência de Glucosefosfato Desidrogenase/dietoterapia , Anemia Hemolítica/etiologia , Doenças Assintomáticas/terapia , Corantes de Alimentos/química , Deficiência de Glucosefosfato Desidrogenase/sangue , Deficiência de Glucosefosfato Desidrogenase/complicações , Humanos , Mentol/efeitos adversos , Naftalenos/química , Pólen/efeitos adversos , Prunus persica/efeitos adversos , Trigonella/efeitos adversos , Vicia faba/efeitos adversosAssuntos
Acetilcisteína/uso terapêutico , Sequestradores de Radicais Livres/uso terapêutico , Deficiência de Glucosefosfato Desidrogenase/dietoterapia , Transtornos Mentais/dietoterapia , Adulto , Deficiência de Glucosefosfato Desidrogenase/complicações , Humanos , Masculino , Transtornos Mentais/complicaçõesRESUMO
The purpose of this study was to examine the effect of α-lipoic acid (LA) supplementation on blood redox status in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Eight adults with G6PD deficiency (D group) and eight controls with normal G6PD levels (N group) participated in this study. Participants received LA (600 mg/day) for 28 days. At baseline, 2 and 4 weeks after supplementation, venous blood was collected for analysis of reduced glutathione (GSH), catalase, protein carbonyls (PC), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), bilirubin, uric acid (UA) and hemoglobin (Hb) levels. Baseline GSH was lower (P<0.05) in D compared to N group whereas LA supplementation for 2 and 4 weeks increased significantly (P<0.05) GSH levels in both groups. Catalase and TAC increased (P<0.05) in both groups following 2 and 4 weeks of supplementation. Baseline TBARS values were higher (P<0.05) in D compared to N group while LA supplementation reduced (P<0.05) TBARS and PC in both groups. There were no differences for UA at baseline between the two groups but LA supplementation increased significantly UA levels only in the D group. Bilirubin and Hb were unchanged. These results indicate that LA supplementation may modulate redox status regardless G6PD deficiency.
